(6-Nitro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol → (6-Amino-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

HRID 970673ノート

反応式

HRID 970673 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]2[O:8][CH:9]([CH2:12][OH:13])[CH2:10][O:11][C:6]=2[CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:15]=[CH:14][C:7]2[O:8][CH:9]([CH2:12][OH:13])[CH2:10][O:11][C:6]=2[CH:5]=1

参加物

4

反応物 1

HCID 12736691(6-Nitro-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol

生成物 1

HCID 21988145(6-Amino-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol収率 77%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(6-Nitro-2,3-dihydro-benzo[1,4]dioxin-2-yl)-methanol (1.0 g, 4.7 mmol) was dissolved in methanol (30 mL) and palladium on activated carbon was added (0.10 g, 5% wt). The mixture was shaken on a Parr Shaker under H2(g) atmosphere (60 PSI) for 24 hours. The mixture was filtered through Celite® and evaporated to give 646 mg of material as a white solid (77%), which was used as such for the next step. m/z=182 (M+1). LC: 0.82 minutes.

後処理

  1. filtrationThe mixture was filtered through Celite®
  2. customevaporated

出典と根拠

ORDレコード
ord-3d03f55831d34db38dde51eea5611991
出典データセット
uspto-grants-2007_12
特許番号
US07312233B2

反応ノート

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