N-bromobutanimide → 5-Bromomethyl-2-phenylbenzoxazole

HRID 970815

反応式

HRID 970815 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1.C1C(=O)N([Br:24])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:24][CH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 819192-Phenyl-5-methylbenzoxazole

生成物 1

HCID 220628305-Bromomethyl-2-phenylbenzoxazole収率 70.6%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

5-methyl-2-phenylbenzoxazole 55 (1.23 g, 5.8 mmol) and NBS (1.17 g, 6.5 mmol) were dissolved in carbon tetrachloride (20 ml). The mixture was evacuated and flushed with argon. AIBN (ca. 5 mg) was added and the mixture heated at reflux and irradiated with a sun lamp for 3 hrs. The solvent was evaporated under reduced pressure and the residue purified by chromatography to yield 1.18 g of 5-bromomethyl-2-phenylbenzoxazole 56.

後処理

  1. customThe mixture was evacuated
  2. customflushed with argon
  3. additionAIBN (ca. 5 mg) was added
  4. temperaturethe mixture heated
  5. temperatureat reflux
  6. customirradiated with a sun lamp for 3 hrs
  7. customThe solvent was evaporated under reduced pressure
  8. customthe residue purified by chromatography

出典と根拠

ORDレコード
ord-eb9dbe3002d5486b851532fe58298dde
出典データセット
uspto-grants-2007_12
特許番号
US07312230B2

関連ノート

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