Hydrochloric Acid → 4-{3-[3,4-Bis(hydroxymethyl)phenyl]propyl}-2-ethylphenol

HRID 970842ノート

反応式

HRID 970842 の反応式
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:14]=[C:15]([C:23](OC)=[O:24])[C:16](=[CH:21][CH:22]=2)[C:17](OC)=[O:18])[CH:6]=[CH:7][C:8]=1[OH:9])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+].Cl>C(OCC)C.O>[OH:24][CH2:23][C:15]1[CH:14]=[C:13]([CH2:12][CH2:11][CH2:10][C:5]2[CH:6]=[CH:7][C:8]([OH:9])=[C:3]([CH2:1][CH3:2])[CH:4]=2)[CH:22]=[CH:21][C:16]=1[CH2:17][OH:18]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 17983037Dimethyl 4-[3-(3-ethyl-4-hydroxyphenyl)propyl]phthalateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 694919444-{3-[3,4-Bis(hydroxymethyl)phenyl]propyl}-2-ethylphenol

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 3283Diethyl Ether溶媒

実験手順

1.7 g (4.8 mmol) of dimethyl 4-[3-(3-ethyl-4-hydroxyphenyl)propyl]phthalate (Example 1f are dissolved in 50 ml of ethyl ether, and this solution is slowly added to a suspension of 435 mg (11.4 mmol) of lithium aluminum hydride. The medium is stirred for 30 minutes and is then sequentially treated with 450 μl of water, 450 μl of 15% sodium hydroxide and 1.5 ml of water. The reaction medium is poured into a 1N hydrochloric acid solution, and extracted with ethyl ether. A white solid is obtained (m=1.2 g, m.p.=82° C., y=84%).

後処理

  1. extractionextracted with ethyl ether
  2. customA white solid is obtained (m=1.2 g, m.p.=82° C., y=84%)

出典と根拠

ORDレコード
ord-4cbc5384fc2742e79d5cd97654289acc
出典データセット
uspto-grants-2007_12
特許番号
US07312249B2

反応ノート

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