Hydrochloric Acid → 7-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(1,3,3-trimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine

HRID 971260ノート

反応式

HRID 971260 の反応式
[Cl:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:15]3[C:14]([NH:18][C:19]4[CH:27]=[C:26]5[C:22]([C:23]([CH3:29])([CH3:28])[CH2:24][NH:25]5)=[CH:21][CH:20]=4)=[N:13][CH:12]=[N:11][C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.Cl.[C:31]([O-])([O-])=O.[K+].[K+].CI>CN(C=O)C.O>[Cl:1][C:2]1[C:3]([N:8]2[CH2:17][CH2:16][C:15]3[C:14]([NH:18][C:19]4[CH:27]=[C:26]5[C:22]([C:23]([CH3:29])([CH3:28])[CH2:24][N:25]5[CH3:31])=[CH:21][CH:20]=4)=[N:13][CH:12]=[N:11][C:10]=3[CH2:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 120041027-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(3,3-dimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine

生成物 1

HCID 120041037-(3-Chloropyridin-2-yl)-5,6,7,8-tetrahydro-n-(1,3,3-trimethylindolin-6-yl)pyrido[3,4-d]pyrimidin-4-amine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of compound of Example 69 hydrogen chloride (20 mg) in DMF (5 mL) was added K2CO3 (50 mg), followed by MeI (50 μL). The mixture was stirred at room temperature for 2 h, and then treated with water, extracted with EtOAc (50 mL). The organic layer was separated, washed with brine, dried (Na2SO4), and evaporated. The residue was purified by flash chromatography over silica ghel to give a light yellow solid (10 mg).

後処理

  1. extractionextracted with EtOAc (50 mL)
  2. customThe organic layer was separated
  3. washwashed with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated
  6. customThe residue was purified by flash chromatography over silica ghel

出典と根拠

ORDレコード
ord-8af38c3f5dad42db993a610dd6212e26
出典データセット
uspto-grants-2007_12
特許番号
US07312330B2

反応ノート

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