HCID 59021684、化合物 → HCID 11626867、化合物

HRID 971311ノート

反応式

HRID 971311 の反応式
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]([C:29]2[CH:34]=[CH:33][C:32]([CH3:35])=[CH:31][CH:30]=2)[CH2:14][C:15]([NH:17]/[N:18]=[CH:19]/[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N+:26]([O-])=O)=[O:16])(=[O:12])=[O:11])=[CH:6][CH:5]=1)[CH3:2]>C(Cl)Cl.[Pd]>[NH2:26][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1/[CH:19]=[N:18]/[NH:17][C:15](=[O:16])[CH2:14][N:13]([C:29]1[CH:30]=[CH:31][C:32]([CH3:35])=[CH:33][CH:34]=1)[S:10]([C:7]1[CH:6]=[CH:5][C:4]([O:3][CH2:1][CH3:2])=[CH:9][CH:8]=1)(=[O:12])=[O:11]

参加物

4

反応物 1

HCID 59021684HCID 59021684、化合物

生成物 1

HCID 11626867HCID 11626867、化合物収率 76.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6344Dichloromethane溶媒

実験手順

4-ethoxy-N-(4-methylphenyl)-N-{2-[(2E)-2-(2-nitrobenzylidene)hydrazino]-2-oxoethyl}benzenesulfonamide (99 mg, 0.2 mmol) was dissolved in methylene chloride. Palladium 5% on charcoal was added (10 mol %). The mixture was stirred under H2 at athmospheric pressure at room temperature overnight. It was filtered on Celite and solvents were evaporated. The expected product, e.g. N-{2-[(2E)-2-(2-aminobenzylidene)hydrazino]-2-oxoethyl}-4-ethoxy-N-(4-methylphenyl)benzenesulfonamide (71.2 mg, 76%), was obtained as a light yellow solid, in 90.9% purity by HPLC (MaxPlot detection between 230 and 400 nm).

後処理

  1. filtrationIt was filtered on Celite and solvents
  2. customwere evaporated

出典と根拠

ORDレコード
ord-a6cd8e2edeba40da906d6aa8c6cf71c1
出典データセット
uspto-grants-2007_12
特許番号
US07312358B2

反応ノート

読み込み中…