Methyl formate → 2-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one

HRID 971434ノート

反応式

HRID 971434 の反応式
O[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(C)C(=C(C)C(=O)CC1)CC3.C(OC)=O.[OH:27][C@@:28]1(C)[CH2:33][CH2:32][C@H:31]2[C@H:34]3[C@H:44]([CH2:45][CH2:46][C@:29]12[CH3:30])[C@:42]1([CH3:43])[C:37](=[C:38]([CH3:50])[C:39](=[O:49])[C:40](=[CH:47][OH:48])[CH2:41]1)[CH2:36][CH2:35]3.[H-].[Na+]>>[OH:48][CH:47]=[C:40]1[CH2:41][C@@:42]2([CH3:43])[C:37]([CH2:36][CH2:35][C@@H:34]3[C@@H:44]2[CH2:45][CH2:46][C@@:29]2([CH3:30])[C@H:31]3[CH2:32][CH2:33][C@@H:28]2[OH:27])=[C:38]([CH3:50])[C:39]1=[O:49]

参加物

5

反応物 4

HCID 7865Methyl formateHCID 24758Sodium hydrideHCID 2365364-MethyltestosteroneHCID 573496094,17alpha-Dimethyl-2-hydroxymethylene Testosterone

生成物 1

HCID 706032882-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one

実験手順

2-Hydroxymethylene-17β-hydroxy-4-methylandrost-4-en-3-one was prepared from 32.28 g. of 17β-hydroxy-4-methylandrost-4-en-3-one and 32 ml. of methyl formate by a procedure analogous to that of Example 1, part (c) except that sodium hydride (15 g., 50%) was used in place of sodium methoxide. The 20 g. of product obtained was used directly in the next reaction.

後処理

  1. customof product obtained
  2. customwas used directly in the next reaction

出典と根拠

ORDレコード
ord-8c4c7750dc934c27b5fb5795da79a057
出典データセット
uspto-grants-1979_07
特許番号
US04160027

反応ノート

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