Hydrochloric Acid → HCID 131711552、化合物

HRID 971442ノート

反応式

HRID 971442 の反応式
Cl[CH:2](Cl)[C:3]([C:5]1[CH:6]=[CH:7][C:8]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([CH:14]=1)[C:10]([O:12][CH3:13])=[O:11])=[O:4].[Na].Cl.C[OH:27]>>[OH2:4].[O:27]=[CH:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([CH:14]=1)[C:10]([O:12][CH3:13])=[O:11])=[O:4]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 5360545SodiumHCID 71372733Methyl 2-(benzyloxy)-5-(dichloroacetyl)benzoate

生成物 1

HCID 131711552HCID 131711552、化合物

実験手順

5-(Dichloroacetyl)-2-(phenylmethoxy)benzoic acid, methyl ester (2.4 g) was added to sodium (0.34 g) in dry methanol (80 ml). The solution was boiled for 20 min. 0.1 N Hydrochloric acid (40 ml) was added and the solution was boiled for 30 min. The methanol was evaporated off and the mixture was extracted with ether (3×50 ml). The extracts were dried (MgSO4) and evaporated to leave crude 5-(oxoacetyl)-2-(phenylmethoxy)benzoic acid, methyl ester, hydrate as a gum.

後処理

  1. waitthe solution was boiled for 30 min
  2. customThe methanol was evaporated off
  3. extractionthe mixture was extracted with ether (3×50 ml)
  4. dry with materialThe extracts were dried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-46dc6b95a600433e9044b52b15e24bca
出典データセット
uspto-grants-1979_07
特許番号
US04160036

反応ノート

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