Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

HRID 971540ノート

反応式

HRID 971540 の反応式
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]>C(O)(=O)C.[Pd]>[NH2:1][C@H:2]([C:10]([O:12][CH3:13])=[O:11])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6]

参加物

4

反応物 1

HCID 59113197Z-Thr(tbu)-ome

生成物 1

HCID 7018834(2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate収率 96.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

12.92 g (40 mmols) of Z-Thr(tBu)-OMe are hydrogenated in 200 ml of glacial acetic acid and 3 g of Pd on charcoal (10%) at room temperature. The absorption of hydrogen is complete after 1 hour. The solution is freed of the catalyst by filtration and is evaporated under a waterpump vacuum at 35° C. After drying in a high vacuum at 35° C., 7.3 g of an oil result which according to a thin layer chromatogram is homogeneous and is directly used further.

後処理

  1. customat room temperature
  2. customThe absorption of hydrogen
  3. filtrationThe solution is freed of the catalyst by filtration
  4. customis evaporated under a waterpump vacuum at 35° C
  5. customAfter drying in a high vacuum at 35° C.

出典と根拠

ORDレコード
ord-60171766c2f9461b85f221ee39ec732e
出典データセット
uspto-grants-1979_07
特許番号
US04159981

反応ノート

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