Styrene Oxide → HCID 10662045、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH2:14]1[O:22][CH:15]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH2:14][CH:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[OH:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]参加物
4
実験手順
A mixture of 100 g (0.55 mol) of 3,4-dimethoxyphenylethylamine and 66.2 g (0.55 mol) of styrene oxide in 200 ml of tetrahydrofuran was refluxed overnight. The solvent was removed in vacuo. About 500 ml of n-butyl chloride was added to the residue and the mixture cooled slightly. Filtration furnished N-[2-(3,4-dimethoxyphenyl)ethyl]-2-phenyl-2-hydroxyethylamine, m.p. 92°-93°.
後処理
- temperaturewas refluxed overnight
- customThe solvent was removed in vacuo
- additionAbout 500 ml of n-butyl chloride was added to the residue
- temperaturethe mixture cooled slightly
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-742de0446c7c40e9be37699ed0cad3c3
- 出典データセット
- uspto-grants-1979_07
- 特許番号
- US04160765
反応ノート
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