Hydrogen Bromide → HCID 21312053、化合物

HRID 971847ノート

反応式

HRID 971847 の反応式
[BrH:1].O[CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1>>[ClH:12].[Br:1][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Cl:12])[CH:7]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 12296176N-(2-hydroxyethyl)-3-chloroaniline

生成物 1

HCID 21312053HCID 21312053、化合物収率 146.7%

反応条件

温度
124 °C

実験手順

50 gm of 50% hydrobromic acid were slowly added dropwise to 19 gm of the product obtained in step (a), while stirring. The vessel containing the resulting mixture was then connected to a Vigreux-column, and the mixture was heated until a temperature of about 124° C. was reached. After three hours of heating at that temperature, about 35 ml of liquid were distilled off. The residue solidified upon cooling and was purified by washing with acetone, yielding 22 gm of the desired product which had a melting point of 148° C.

後処理

  1. additionThe vessel containing the resulting mixture
  2. distillationwere distilled off
  3. temperatureupon cooling
  4. customwas purified
  5. washby washing with acetone

出典と根拠

ORDレコード
ord-83b0134809ae452fa16118b493989fcc
出典データセット
uspto-grants-1979_07
特許番号
US04161528

反応ノート

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