Ethyl bromoacetate → HCID 54249393、化合物
反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:18][CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>C1C=CC=CC=1>[CH2:24]([O:23][C:21]([CH2:20][N:15]1[CH2:16][CH2:17][CH2:18][CH:14]1[C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:9][CH:10]=1)=[O:22])[CH3:25]参加物
4
実験手順
To a solution of 23.9 parts of 2-(4-phenoxyphenyl) pyrrolidine in 80 parts of anhydrous benzene, there were quickly added 8.35 parts of ethyl bromacetate. The reaction mixture was then refluxed for 4 hours. After cooling and filtration, the residue was treated with 50 parts of water and 100 parts of ether. After decantation, then distillation, there were obtained 11.3 parts of 1-ethoxycarbonylmethyl-2-(4-phenoxyphenyl) pyrrolidine, B.P./0.1 mm Hg: 165° C., nD23 : 1.5524.