Isobutyryl chloride → N-[4-Bromo-3-(trifluoromethyl)phenyl]-2-methylpropanamide
反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](Cl)(=[O:17])[CH:14]([CH3:16])[CH3:15]>N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:13](=[O:17])[CH:14]([CH3:16])[CH3:15])=[CH:4][C:3]=1[C:9]([F:10])([F:11])[F:12]参加物
4
実験手順
To a stirred, cooled solution of 15.0 g. of 4-bromo-3-trifluoromethylaniline is 75 ml. of dry pyridine add 6.8 g. of isobutyrylchloride and heat the resulting mixture at 70° C. for 2 hours. Allow the reaction mixture to cool to room temperature and then pour the mixture into 600 ml. of ice-water, filter and dry the precipitate which is recrystallised from 1:1 petroleum etherdichloromethane to yield 4'-bromo-3'-trifluoromethylisobutyranilide, m.p. 126.5°-128° C.
後処理
- temperatureTo a stirred, cooled solution of 15.0 g
- additionpour the mixture into 600 ml
- filtrationof ice-water, filter
- customdry the precipitate which
- customis recrystallised from 1:1 petroleum etherdichloromethane
出典と根拠
- ORDレコード
- ord-39fe64adbdf846afa25cfd58851c33f7
- 出典データセット
- uspto-grants-1979_07
- 特許番号
- US04161540
反応ノート
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