Flutamide → N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide

HRID 971861

反応式

HRID 971861 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:16]([F:19])([F:18])[F:17])([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:15]=[CH:14][C:7]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:16]([F:17])([F:18])[F:19]

参加物

4

反応物 1

HCID 3397Flutamide

生成物 1

HCID 16776651N-[4-Amino-3-(trifluoromethyl)phenyl]-2-methylpropanamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Hydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g. of 4'-nitro-3'-trifluoromethylisobutyranilide in 100 ml. of ethanol containing 0.5 g. of 5% palladium on charcoal. Filter and remove the solvent, obtaining 4'-amino-3'-trifluoromethylisobutyranilide, m.p. 114.5°-116° C.

後処理

  1. additionHydrogenate, at approximately 3 atmospheres, a mixture of 8.3 g
  2. filtrationFilter
  3. customremove the solvent

出典と根拠

ORDレコード
ord-ad37a73163f6419ba8063be514ea3e3c
出典データセット
uspto-grants-1979_07
特許番号
US04161540

関連ノート

読み込み中…