Water → 2-[4-(2-Hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionic Acid

HRID 971873ノート

反応式

HRID 971873 の反応式
[OH:1][N:2]=[C:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([CH3:22])[C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=1.[OH-].[Na+].O>CO>[OH:1][N:2]=[C:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[CH2:9][C:10]1[CH:11]=[CH:12][C:13]([CH:16]([CH3:22])[C:17]([OH:19])=[O:18])=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 73769774Ethyl 2-[4-(2-Hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionate

生成物 1

HCID 737697732-[4-(2-Hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Three grams of ethyl 2-[4-(2-hydroxyiminocyclohexan-1-ylmethyl)phenyl]propionate and 0.8 g of sodium hydroxide were dissolved in 50 ml of methanol and the solution was allowed to stand at room temperature overnight. To the reaction mixture was added 20 ml of water, methanol was removed by distillation and the residue was acidified with hydrochloric acid to precipitate crystals, which were collected by filtration and recrystallized from a mixture of ether and n-hexane affording 2.1 g of colorless crystals, m.p. 148°-150° C.

後処理

  1. customwas removed by distillation
  2. customto precipitate crystals, which
  3. filtrationwere collected by filtration
  4. customrecrystallized from a mixture of ether and n-hexane affording 2.1 g of colorless crystals, m.p. 148°-150° C.

出典と根拠

ORDレコード
ord-d5934c83d7b84a198ef2e8f3fc75c6da
出典データセット
uspto-grants-1979_07
特許番号
US04161538

反応ノート

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