Isopropylamine → HCID 12801064、化合物

HRID 972003ノート

反応式

HRID 972003 の反応式
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]2[CH2:13][N:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:11][C:10](=[O:20])[O:9]2)=[CH:4][CH:3]=1.[CH:23]([NH2:26])([CH3:25])[CH3:24]>O1CCOCC1>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][CH2:7][CH:8]([OH:9])[CH2:13][N:12]([CH2:11][C:10]([NH:26][CH:23]([CH3:25])[CH3:24])=[O:20])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 6363IsopropylamineHCID 203059606-[(4-Chlorophenoxy)methyl]-4-phenylmorpholin-2-one

生成物 1

HCID 12801064HCID 12801064、化合物収率 10.5%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

After 7.0 g (0.22 moles) of 6-(p-chlorophenoxymethyl)-4-phenyl-2-morpholinone and 20 g of isopropylamine were dissolved in 50 ml of dioxane and the resulting Solution was left to stand overnight at room temperature, the reaction mixture was concentrated in vacuo. The residue was solidified by addition of a small amount of ether. The solid was filtered, washed with ether and dried to give 8.7 g of the product. Recrystallization from ethanol afforded 5.5 g (66.3%) of crystals, with a melting point of 140.5° to 142.5°.

後処理

  1. waitthe resulting Solution was left
  2. concentrationthe reaction mixture was concentrated in vacuo
  3. additionThe residue was solidified by addition of a small amount of ether
  4. filtrationThe solid was filtered
  5. washwashed with ether
  6. customdried

出典と根拠

ORDレコード
ord-a51548dc85ff449aa968922aa3098828
出典データセット
uspto-grants-1979_07
特許番号
US04162331

反応ノート

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