Dimethyl Sulfoxide → HCID 70606727、化合物
反応式
[CH3:1][N:2]([CH3:11])[C:3]1[C:4](C)=[CH:5][C:6](O)=[CH:7][CH:8]=1.ClC[C:14]#[N:15].[CH3:16]S(C)=O.[C:20]([O-:23])([O-])=O.[K+].[K+]>O>[CH3:11][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([CH3:16])=[CH:5][C:4]=1[O:23][CH2:20][C:14]#[N:15]参加物
6
実験手順
30.2 Grams of 4-dimethylamino-m-cresol and 16.0 grams of chloroacetonitrile were dissolved in 50 ml. of dimethylsulfoxide. Anhydrous K2CO3 (39.6 g) was added as a catalyst. The mixture was heated with stirring to 70°-80° C. for three hours. The reaction mixture was poured into approximately 2 liters of a ice and water mixture. The product was extracted with methylene chloride. The extract was dried with SEA SORB® and activated charcoal and the resulting mixture was filtered. The filtrate was dried under vacuum to yield 4-dimethylamino-m-tolyloxyacetonitrile.
後処理
- temperatureThe mixture was heated
- extractionThe product was extracted with methylene chloride
- dry with materialThe extract was dried with SEA SORB® and activated charcoal
- filtrationthe resulting mixture was filtered
- customThe filtrate was dried under vacuum
出典と根拠
- ORDレコード
- ord-08cdd671e4394d8baa938d5b9f1ae3b5
- 出典データセット
- uspto-grants-1979_07
- 特許番号
- US04163105
反応ノート
読み込み中…