Ammonia → 2-((4-Amino-6-chloro-1,3,5-triazin-2-yl)oxy)phenol

HRID 972187ノート

反応式

HRID 972187 の反応式
[N:1]1[C:8]([Cl:9])=[N:7][C:5](Cl)=[N:4][C:2]=1Cl.[NH3:10].[C:11]1([C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[OH:14])[OH:12]>O.[OH-].[Na+]>[NH2:10][C:2]1[N:1]=[C:8]([Cl:9])[N:7]=[C:5]([O:12][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[OH:14])[N:4]=1

参加物

6

反応物 3

HCID 222AmmoniaHCID 289CatecholHCID 7954Cyanuric chloride

生成物 1

HCID 64543042-((4-Amino-6-chloro-1,3,5-triazin-2-yl)oxy)phenol

試薬・触媒・溶媒 2

HCID 962Water溶媒5 回HCID 14798Sodium Hydroxide溶媒2 回

反応条件

温度
35 °C

実験手順

A suspension of 36.9 parts of cyanuric chloride in 250 parts of water at 0°-5° C was prepared. To the stirred suspension at this temperature were added separately over about 30 minutes a solution of ammonia (3.4 parts) in water (80 parts) concurrently with a solution of sodium hydroxide (8.0 parts) in water (80 parts). Stirring was continued at 0°-5° C for about 90 minutes after completion of the addition. The temperature of the mixture was then increased to 35° C and solutions of catechol (22 parts) in water (180 parts) and sodium hydroxide (8 parts) in water (70 parts) were added with stirring at this temperature over about 40 minutes. Stirring was continued for about 1 hour at 35° C when the reaction reached neutrality. The reaction mixture was cooled to 10° C and the product isolated by filtration, washed with water and dried. 2-amino-4-chloro-6 -(2'-hydroxyphenoxy)-s-triazine was thereby obtained as an off-white powder of indefinite melting point due to decomposition, analysing for carbon 43.2%, hydrogen 2.6%, nitrogen 23.2% and chlorine 14.3%. (C9H7ClN4O2 requires carbon 45.3%, hydrogen 2.9%, nitrogen 23.5% and chlorine 14.9%).

後処理

  1. customwas prepared
  2. additionafter completion of the addition
  3. stirringwith stirring at this temperature over about 40 minutes
  4. stirringStirring
  5. waitwas continued for about 1 hour at 35° C
  6. temperatureThe reaction mixture was cooled to 10° C
  7. customthe product isolated by filtration
  8. washwashed with water
  9. customdried

出典と根拠

ORDレコード
ord-6a57544de22c4e39b17a9257f136a069
出典データセット
uspto-grants-1977_10
特許番号
US04052392

反応ノート

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