Thionyl Chloride → Methyl 7-phthalimido-3-methylenecepham-4-carboxylate 1-oxide

HRID 972228ノート

反応式

HRID 972228 の反応式
[CH3:1][C:2](=[CH2:27])[CH:3]([N:8]1[C:11](=[O:12])[CH:10]([N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[CH:9]1[S:24]([OH:26])=O)[C:4]([O:6][CH3:7])=[O:5].S(Cl)(Cl)=O>>[C:17]1(=[O:18])[N:13]([CH:10]2[C:11](=[O:12])[N:8]3[CH:3]([C:4]([O:6][CH3:7])=[O:5])[C:2](=[CH2:1])[CH2:27][S:24](=[O:26])[C@H:9]23)[C:14](=[O:23])[C:15]2=[CH:22][CH:21]=[CH:20][CH:19]=[C:16]12

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 21314440Methyl 3-methyl-2-(2-sulfino-4-oxo-3-phthalimido-1-azetidinyl)-3-butenoate

生成物 1

HCID 69799987Methyl 7-phthalimido-3-methylenecepham-4-carboxylate 1-oxide

実験手順

The same procedure was followed as described in Example 1 (L) above except 0.20 g. of methyl 3-methyl-2-(2-sulfino-4-oxo-3-phthalimido-1-azetidinyl)-3-butenoate was employed as the starting material instead of the corresponding sulfinyl chloride. An nmr spectrum of the product showed the title compound to be the major constituent.

出典と根拠

ORDレコード
ord-8e66050461b24e5baa8bf79b84a3911e
出典データセット
uspto-grants-1977_10
特許番号
US04052387

反応ノート

読み込み中…