Sodium Hydroxide → HCID 21406751、化合物
反応式
[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9](N)=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[F:19].[OH-:20].[Na+]>O>[F:1][C:2]1[CH:7]=[C:6]([CH2:8][C:9]([OH:20])=[O:10])[CH:5]=[CH:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[F:19]参加物
4
実験手順
A mixture of 2,2',4'-trifluoro-4-biphenylylacetamide (100 mg.), aqueous caustic soda (18N; 1 ml.) and water (5 ml.) was stirred under reflux overnight. The mixture was acidified and extracted with ether. The ether was evaporated and the product recrystallised from 80-100 petroleum ether to give 2,2',4'-trifluoro-4-biphenylylacetic acid, m.p. 144°-147° C.
後処理
- temperatureunder reflux overnight
- extractionextracted with ether
- customThe ether was evaporated
- customthe product recrystallised from 80-100 petroleum ether
出典と根拠
- ORDレコード
- ord-7f687811921f4d83968defcb73d9d3e3
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04052514
反応ノート
読み込み中…