Sodium Hydroxide → N-(4,5,6,7-Tetrahydro-1-benzothiophen-4-yl)urea
反応式
C([NH:9][C:10]([NH:12][CH:13]1[C:21]2[CH:20]=[CH:19][S:18][C:17]=2[CH2:16][CH2:15][CH2:14]1)=[O:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>>[S:18]1[CH:19]=[CH:20][C:21]2[CH:13]([NH:12][C:10]([NH2:9])=[O:11])[CH2:14][CH2:15][CH2:16][C:17]1=2参加物
3
実験手順
A mixture of 1-benzoyl-3-(4,5,6,7-tetrahydrobenzo-[b]thien-4-yl) urea and 2N aqueous sodium hydroxide solution (5ml) is stirred at reflux for 2.5 hours. The mixture is cooled in ice, the product is collected and washed with water to afford 0.58 g of title compound, m.p. 203° to 207° C.
後処理
- temperatureat reflux for 2.5 hours
- temperatureThe mixture is cooled in ice
- customthe product is collected
- washwashed with water
出典と根拠
- ORDレコード
- ord-14391dd763914b96a03eb547db6e1b88
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04053484
反応ノート
読み込み中…