Hydrochloric Acid → 4-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

HRID 972522

反応式

HRID 972522 の反応式
[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[CH:5]([NH:11]C(=O)C)[CH2:4][CH2:3]1.Cl.[OH-].[Na+].[Cl-].[Na+]>O>[O:1]=[C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[CH:5]([NH2:11])[CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 106675Acetamide, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)-

生成物 1

HCID 233477964-Amino-5,6-dihydro-1-benzothiophen-7(4H)-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of N-(4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-yl)acetamide (16.0 g), water (100 ml) and concentrated hydrochloric acid (100 ml) is stirred and heated at reflux for an overnight period. The mixture is cooled, made alkaline with 50% aqueous sodium hydroxide, and sautrated with sodium chloride. The mixture is then extracted with methylene chloride (3×250 ml). The extracts are combined, dried over magnesium sulfate and then evaporated to dryness in vacuo to afford the title compound as a yellow-brown syrup.

後処理

  1. temperatureheated
  2. temperatureat reflux for an overnight period
  3. temperatureThe mixture is cooled
  4. extractionThe mixture is then extracted with methylene chloride (3×250 ml)
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness in vacuo

出典と根拠

ORDレコード
ord-6a58cab4b11c45658e420f9c562659ad
出典データセット
uspto-grants-1977_10
特許番号
US04053484

関連ノート

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