Sulfuric Acid → 1-Chloro-3-nitrobenzene

HRID 972671

反応式

HRID 972671 の反応式
[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1N.C(O)(C)C.S(=O)(=O)(O)O.N([O-])=O.[Na+]>O>[Cl:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][CH:3]=1

参加物

6

反応物 4

HCID 1118Sulfuric AcidHCID 3776IsopropanolHCID 84922-Chloro-4-nitroanilineHCID 23668193Sodium Nitrite

生成物 1

HCID 84891-Chloro-3-nitrobenzene収率 90%

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

実験手順

172.5 parts of 2-chloro-4-nitro-aniline are introduced into 180 parts of isopropanol and 300 parts of water, and 200 parts of concentrated sulfuric acid (98 percent strength by weight) are then added to the mixture. A solution of 125 parts of NaNO2 in 175 parts of water is run in at 50° C., as described in Example 1. The mixture is cooled, 400 parts of water are added and the product is filtered off. 142 parts (90% of theory) of 3-chloro-nitro-benzene, of melting point 40°-42° C., are obtained.

後処理

  1. additionare then added to the mixture
  2. customis run in at 50° C.
  3. temperatureThe mixture is cooled
  4. filtrationthe product is filtered off

出典と根拠

ORDレコード
ord-bb2327d0a7014402a0420096593a1132
出典データセット
uspto-grants-1977_10
特許番号
US04053527

関連ノート

読み込み中…