3-Methyl-2-butanone → HCID 21443884、化合物

HRID 972709

反応式

HRID 972709 の反応式
[CH:1]([C:4]([CH3:6])=[O:5])([CH3:3])[CH3:2].Cl[CH:8]([Cl:16])[C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>O1CCCC1>[Cl:16][C:8]1([O:5][C:4]1([CH:1]([CH3:3])[CH3:2])[CH3:6])[C:9]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:10]

参加物

4

反応物 2

HCID 112513-Methyl-2-butanoneHCID 30164831,1-Dimethylethyl dichloroacetate

生成物 1

HCID 21443884HCID 21443884、化合物収率 98.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 122 g of potassium tert.-butylate in 720 ml of tetrahydrofuran was added at -20° C. with stirring under an inert atmosphere to a mixture of 95 g of methyl isopropyl ketone and 185 g of tert.butyl dichloroacetate and after returning the temperature to room temperature, the mixture was stirred for 2 hours. The mixture was poured into ice water and the mixture was stirred and the organic phase was separated. The organic phase was washed with aqueous sodium chloride solution, dried over magnesium sulfate, passed through vegetable charcoal and concentrated to dryness to obtain 230.4 g of tert.butyl 2-chloro-2,3-epoxy-3-isopropyl-butanoate.

後処理

  1. customto room temperature
  2. stirringthe mixture was stirred
  3. customthe organic phase was separated
  4. washThe organic phase was washed with aqueous sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-d9affb2b65f3455eaf12a6d03e58495f
出典データセット
uspto-grants-1977_10
特許番号
US04053597

関連ノート

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