Ethanolamine → N-(2-Hydroxyethyl)-2-methyl-5-nitropyridine-3-carboxamide
反応式
[CH3:1][C:2]1[N:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:3]=1[C:4]([O:6]CC)=O.[NH2:16][CH2:17][CH2:18][OH:19]>C(O)C>[OH:19][CH2:18][CH2:17][NH:16][C:4](=[O:6])[C:3]1[CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=[N:12][C:2]=1[CH3:1]参加物
4
実験手順
A mixture of ethyl 2-methyl-5-nitronicotinate (1 g.) and 2-aminoethanol (4 ml.) in ethanol (5ml.) was stirred at room temperature for 16 hours. The solvent was distilled off, the residue was purified by silica gel chromatography and recrystallized from ethyl acetate n-hexane to give the desired yellow crystals. mp 144° - 145° C.
後処理
- distillationThe solvent was distilled off
- customthe residue was purified by silica gel chromatography
- customrecrystallized from ethyl acetate n-hexane
- customto give the desired yellow crystals
出典と根拠
- ORDレコード
- ord-e50f24c5f5de465a89c287c68e8b8281
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04053608
反応ノート
読み込み中…