Potassium Carbonate → HCID 13023013、化合物
反応式
[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][C:11](OC)=[CH:10][C:9]=2[OH:16])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:23]([CH:25]1[O:27][CH2:26]1)Br>CC(=O)CC>[Cl:1][C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:16][CH2:23][CH:25]2[O:27][CH2:26]2)=[CH:4][CH:3]=1参加物
5
実験手順
i. A stirred mixture of 6-chloro-3-(2-hydroxy-4-methoxyphenyl)pyridazine (0.1 mole), potassium carbonate (0.3 mole) and epibromohydrin (0.4 mole) in butan-2-one was heated under reflux overnight. The filtered solution was evaporated to give an oil which was purified by elution with mixtures of chloroform-methanol on a silica column to give 6-chloro-3-[2-(2,3-epoxypropoxy)phenyl]pyridazine.
後処理
- temperaturewas heated
- temperatureunder reflux overnight
- customThe filtered solution was evaporated
- customto give an oil which
- customwas purified by elution with mixtures of chloroform-methanol on a silica column
出典と根拠
- ORDレコード
- ord-35d0b7c7856a4cb9ae74df3f94adaff4
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04053601
反応ノート
読み込み中…