p-Piperidinophenol → HCID 21405650、化合物

HRID 972890ノート

反応式

HRID 972890 の反応式
[Na].[N:2]1([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.Br[CH:16]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:17]([O:19]CC)=[O:18]>C(O)C>[C:22]1([CH:16]([O:14][C:11]2[CH:10]=[CH:9][C:8]([N:2]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]3)=[CH:13][CH:12]=2)[C:17]([OH:19])=[O:18])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

参加物

5

反応物 3

HCID 90452p-PiperidinophenolHCID 97780Ethyl bromophenylacetateHCID 5360545Sodium

生成物 1

HCID 21405650HCID 21405650、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.3 g. of sodium is dissolved in 100 ml. of absolute ethanol; 17.7 g. of 4-piperidinophenol is introduced into the solution, and then 24.3 g. of ethyl α-bromophenylacetate is added dropwise thereto and the mixture refluxed for 10 hours. The reaction mixture is then evaporated, the residue mixed with water, and the aqueous solution extracted with ethyl acetate. The ethyl acetate solution is washed twice with dilute KOH and twice with water, then dried, and the solvent is evaporated, thus obtaining the ethyl ester of α-phenyl-α-4-piperidinophenoxy-acetic acid; hydrochloride, m.p. 149°-151°.

後処理

  1. temperaturethe mixture refluxed for 10 hours
  2. customThe reaction mixture is then evaporated
  3. additionthe residue mixed with water
  4. extractionthe aqueous solution extracted with ethyl acetate
  5. washThe ethyl acetate solution is washed twice with dilute KOH and twice with water
  6. customdried
  7. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-99c6fc8562064e6bad38c78bb67fceca
出典データセット
uspto-grants-1977_10
特許番号
US04053626

反応ノート

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