Cyclohexene → Ethyl 2-[(3-amino-2-cyanophenyl)amino]-2-oxoacetate
反応式
[CH2:1]([O:3][C:4](=[O:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[C:9]=1[C:17]#[N:18])=[O:6])[CH3:2].C1CCCCC=1>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[C:9]=1[C:17]#[N:18])=[O:6])[CH3:2]参加物
5
実験手順
The title compound is prepared by reduction of [3-nitro-2-cyanophenylamino]oxoacetic acid ethyl ester with 10% Pd. on charcoal and with cyclohexene in ethanol according to the procedure of I. D. Entwistle and R. A. W. Johnstone, J. Chem. Soc., Perkin I. 1300 (1975). The crude product is chromatographed on silica gel with chloroform and recrystallized from ethanol, m.p. 133°-136° C.
後処理
- customThe crude product is chromatographed on silica gel with chloroform
- customrecrystallized from ethanol, m.p. 133°-136° C.
出典と根拠
- ORDレコード
- ord-0db0fc8397e54c9485d0e0d7ea338c79
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04054591
反応ノート
読み込み中…