Tert-Butyl hypochlorite → 7-(1-Chloro-2,6-dioxocyclohexyl)-5-heptynoic acid methyl ester

HRID 973101ノート

反応式

HRID 973101 の反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][C:7]#[C:8][CH2:9][CH:10]1[C:15](=[O:16])[CH2:14][CH2:13][CH2:12][C:11]1=[O:17].[Cl:19]OC(C)(C)C>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][C:7]#[C:8][CH2:9][C:10]1([Cl:19])[C:15](=[O:16])[CH2:14][CH2:13][CH2:12][C:11]1=[O:17]

参加物

4

反応物 2

HCID 521297Tert-Butyl hypochloriteHCID 13873492Methyl 7-(2,6-dioxocyclohexyl)hept-5-ynoate

生成物 1

HCID 544782317-(1-Chloro-2,6-dioxocyclohexyl)-5-heptynoic acid methyl ester

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
20 °C

実験手順

7-(2,6-Dioxocyclohexyl)-5-heptynoic acid methyl ester (21.0 g), prepared as described in Example 13, is dissolved in chloroform (300 ml) cooled to 20° C and t-butyl hypochlorite (9.5 g) in chloroform (10 ml) is added to the well stirred solution over a period of 15 minutes. The mixture is stirred for another 30 minutes and allowed to warm up to room temperature. Removal of the solvent affords 7-(1-chloro-2,6-dioxocyclohexyl)-5-heptynoic acid methyl ester, γmaxFilm 1730, 1720.

後処理

  1. stirringThe mixture is stirred for another 30 minutes
  2. temperatureto warm up to room temperature
  3. customRemoval of the solvent

出典と根拠

ORDレコード
ord-a3a43de654304c7c82fb0bc39e7c15d9
出典データセット
uspto-grants-1977_10
特許番号
US04054741

反応ノート

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