Sulfuric Acid → (4S)-4-hydroxy-2-nonynal
反応式
C([O:3][CH:4](OCC)[C:5]#[C:6][C@@H:7]([O:13]C1CCCCO1)[CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])C.O1CCCC1.S(=O)(=O)(O)O>O>[OH:13][C@@H:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:6]#[C:5][CH:4]=[O:3]参加物
5
実験手順
A mixture of (4S)-1,1-diethoxy-4-(2-tetrahydropyranyloxy)-2-nonyne (96.0 g., 0.31 mole), tetrahydrofuran (500 ml.), and 30% aqueous sulfuric acid (100 ml.) is stirred at room temperature for 17 hours. The solution is diluted with water and the oily product is extracted with ether. The ether extract is washed with sodium bicarbonate solution and water and dried over sodium sulfate. Evaporation of the ether leaves (4S)-4-hydroxy-2-nonynal as a colorless residual oil which is used in the following step without further purification.
後処理
- extractionthe oily product is extracted with ether
- extractionThe ether extract
- washis washed with sodium bicarbonate solution and water
- dry with materialdried over sodium sulfate
- customEvaporation of the ether
出典と根拠
- ORDレコード
- ord-5ec0650efd8c43c8a75b3564ee94104e
- 出典データセット
- uspto-grants-1977_10
- 特許番号
- US04055597
反応ノート
読み込み中…