Malonic Acid → 3-(2-Bromo-5-nitrophenyl)prop-2-enoic acid

HRID 973378ノート

反応式

HRID 973378 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:14][C:15]([OH:17])=[O:16].N1CCCCC1>N1C=CC=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH:4]=[CH:14][C:15]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 867Malonic AcidHCID 8082PiperidineHCID 111389422-Bromo-5-nitrobenzaldehyde

生成物 1

HCID 541062433-(2-Bromo-5-nitrophenyl)prop-2-enoic acid収率 57%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

This reaction was carried out similarly to Example 1, with 2-bromo-5-nitrobenzaldehyde and malonic acid in pyridine and with piperidine. The product of melting point 185° C. was obtained in 57% yield.

後処理

  1. customThe product of melting point 185° C. was obtained in 57% yield

出典と根拠

ORDレコード
ord-d8ed299732b544fb90ef6cfb27f10583
出典データセット
uspto-grants-1991_11
特許番号
US05062884

反応ノート

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