4-Hydroxybenzaldehyde → 4-[(3-Chlorophenyl)methoxy]benzaldehyde

HRID 973392ノート

反応式

HRID 973392 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]Cl>C(C(C)=O)C>[Cl:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1264-HydroxybenzaldehydeHCID 11430Potassium CarbonateHCID 12103m,alpha-Dichlorotoluene

生成物 1

HCID 7354654-[(3-Chlorophenyl)methoxy]benzaldehyde収率 88.2%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

18.3 g of p-hydroxybenzaldehyde is dissolved in 200 ml of methyl ethyl ketone, and then 22.8 g of potassium carbonate and 24.2 g of m-chlorobenzyl chloride are added thereto. The resulting mixture is refluxed for 8 hours in a stream of nitrogen. Insoluble substances produced are removed by filtration, and then the solvent is distilled away. The resulting residue is distilled under reduced pressure to obtain 32.6 g of 4-(3-chlorobenzyloxy)benzaldehyde in the form of white crystal.

後処理

  1. temperatureThe resulting mixture is refluxed for 8 hours in a stream of nitrogen
  2. customInsoluble substances produced
  3. customare removed by filtration
  4. distillationthe solvent is distilled away
  5. distillationThe resulting residue is distilled under reduced pressure

出典と根拠

ORDレコード
ord-078a98a913304fd1865101b59fb60f94
出典データセット
uspto-grants-1991_11
特許番号
US05063197

反応ノート

読み込み中…