Pyridine → 4-((1R,2S)-1-cyano-2-hexylcyclopropyl)phenyl (S)-4-[4-(2-propoxypropanoyloxy)phenyl]benzoate

HRID 973521ノート

反応式

HRID 973521 の反応式
[CH2:1]([O:4][C@@H:5]([CH3:24])[C:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)=[O:7])[CH2:2][CH3:3].[C:25]([C@:27]1([C:36]2[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=2)[CH2:29][C@@H:28]1[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])#[N:26].N1C=CC=CC=1.CCOCC>ClCCl>[CH2:1]([O:4][C@@H:5]([CH3:24])[C:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([O:42][C:39]3[CH:38]=[CH:37][C:36]([C@@:27]4([C:25]#[N:26])[CH2:29][C@@H:28]4[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[CH:41][CH:40]=3)=[O:20])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)=[O:7])[CH2:2][CH3:3]

参加物

6

反応物 4

HCID 1049PyridineHCID 3283Diethyl EtherHCID 14573372(S)-4-[4-(2-propoxypropanoyloxy)phenyl]benzoyl chlorideHCID 15733984(1R,2S)-1-cyano-2-hexyl-1-(4-hydroxyphenyl)cyclopropane

生成物 1

HCID 157339934-((1R,2S)-1-cyano-2-hexylcyclopropyl)phenyl (S)-4-[4-(2-propoxypropanoyloxy)phenyl]benzoate収率 46%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 10 ml of dichloromethane were dissolved 83 mg of (S)-4-[4-(2-propoxypropanoyloxy)phenyl]benzoyl chloride and 65 mg of (1R,2S)-1-cyano-2-hexyl-1-(4-hydroxyphenyl)cyclopropane. To this solution was added 0.5 ml of pyridine. The resulting mixture was stirred for 3 hours under reflux. The reaction mixture was cooled, and then ether was added thereto. The ethanol phase was separated, washed with diluted hydrochloric acid, water, and then saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation and the residue was purified by silica gel column chromatography (solvent: hexane/ethyl acetate=5/1). Recrystallization from ethanol afforded, thereby obtaining 61 mg of the desired compound as colorless crystals.

後処理

  1. temperatureunder reflux
  2. temperatureThe reaction mixture was cooled
  3. customThe ethanol phase was separated
  4. washwashed with diluted hydrochloric acid, water
  5. dry with materialsaturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate
  6. customThe solvent was removed by evaporation
  7. customthe residue was purified by silica gel column chromatography (solvent: hexane/ethyl acetate=5/1)
  8. customRecrystallization from ethanol
  9. customafforded

出典と根拠

ORDレコード
ord-276cbc39877e44178f957c4dbba6edec
出典データセット
uspto-grants-1991_11
特許番号
US05064564

反応ノート

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