O-Toluidine → HCID 10332347、化合物
反応式
[NH2:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:13][C:14]1[C:15]([CH3:20])=[CH:16][CH:17]=[CH:18][CH:19]=1>C(O)C>[NH2:1][C:2]1[N:11]=[C:10]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
4
実験手順
2-Amino-4-chloroquinazoline (0.64 g, 0.0036 mol) was heated to 170° in o-toluidine (1 ml, 0.008 mol) for 1 hour. The reaction mixture was dissolved in ethanol, stripped and partitioned between chloroform and NaOH solution (pH 9). The organic solution was dried, filtered and excess solvent removed to give an oil which afforded crystals of 2-amino-4-(2-methylphenylamino)-quinazoline (0.55 g, 62%) m.p. 273°-275° (from ethanol).
後処理
- custompartitioned between chloroform and NaOH solution (pH 9)
- customThe organic solution was dried
- filtrationfiltered
- customexcess solvent removed
- customto give an oil which
出典と根拠
- ORDレコード
- ord-fe260666ec40421e802a18037708db9a
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05064833
反応ノート
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