tert-butyl N-(4-aminobutyl)carbamate → N-(tert-butoxycarbonyl)-N'-(1-naphthyl acetyl)-1,4-diamino-butane

HRID 973729

反応式

HRID 973729 の反応式
[C:1]1([CH2:11][C:12](Cl)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])=[O:21])([CH3:18])([CH3:17])[CH3:16].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][NH:27][C:12](=[O:13])[CH2:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:21])([CH3:18])([CH3:17])[CH3:16]

参加物

5

反応物 3

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 8471TriethylamineHCID 27953862-(Naphthalen-1-yl)acetyl chloride

生成物 1

HCID 19989015N-(tert-butoxycarbonyl)-N'-(1-naphthyl acetyl)-1,4-diamino-butane収率 97.9%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

A solution of 16.3 g of 1-naphthyl-acetic acid chloride in 80 ml of chloroform was added at +10° C. to a solution cooled to +10° C. of 15 g of N-(tert-butoxycarbonyl)-1,4-diamino butane, 100 ml of chloroform and 14 ml of triethylamine and after one hour of stirring at ambient temperature, the mixture was concentrated to dryness under reduced pressure. The residue was taken up in water, separated and dried under reduced pressure at 50° C. to obtain 27.8 g of the expected product.

後処理

  1. concentrationthe mixture was concentrated to dryness under reduced pressure
  2. customseparated
  3. customdried under reduced pressure at 50° C.

出典と根拠

ORDレコード
ord-62f119eefb404bb29accddb1e10d90ea
出典データセット
uspto-grants-1991_11
特許番号
US05064861

関連ノート

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