4-Sulfamoylbenzaldehyde → 4-(2-Cyanoethyl)benzene-1-sulfonamide
反応式
[NH2:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:13]([CH2:15]P(=O)(OCC)OCC)#[N:14].[H-].[Na+]>O1CCCC1>[C:13]([CH2:15][CH2:9][C:8]1[CH:11]=[CH:12][C:5]([S:2]([NH2:1])(=[O:4])=[O:3])=[CH:6][CH:7]=1)#[N:14]参加物
4
実験手順
For the preparation of the amine starting material of Example 24, p-aminosulfonylbenzaldehyde was reacted with diethyl cyanomethylphosphonate/sodium hydride in tetrahydrofuran to give 1-cyano-2-(4-aminosulfonylphenyl)-ethane which was hydrogenated in methanol with Raney-cobalt as the catalyst to give 3-(4-aminosulfonylphenyl)-propylamine.
出典と根拠
- ORDレコード
- ord-814dc3e2e5d1461c9a9a59f4a0a9956c
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05064863
反応ノート
読み込み中…