Dicyclohexylcarbodiimide → HCID 131715158、化合物

HRID 973901ノート

反応式

HRID 973901 の反応式
C1(N=C=NC2CCCCC2)CCCCC1.[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1>N1C=CC=CC=1>[NH2:16][CH2:17][CH2:18][C:19]1[NH:28][C:27]2[C:26](=[O:29])[N:24]([CH3:25])[C:23](=[O:30])[N:22]([CH3:31])[C:21]=2[N:20]=1.[CH:32]1[C:37]([C:38]([OH:40])=[O:39])=[CH:36][C:35]2[C:41]3([O:57][C:58](=[O:59])[C:34]=2[CH:33]=1)[C:51]1[CH:52]=[CH:53][C:54]([OH:56])=[CH:55][C:50]=1[O:49][C:43]1[CH:44]=[C:45]([OH:48])[CH:46]=[CH:47][C:42]3=1

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 768066-CarboxyfluoresceinHCID 4140301AC1N56UX

生成物 1

HCID 131715158HCID 131715158、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

N,N'-dicyclohexylcarbodiimide (15 mg) was added to a solution of 8-β-aminoethyltheophylline (5 mg) and carboxyfluorescein (5 mg) in 0.5 ml of pyridine. The reaction was allowed to proceed for two hours at room temperature and the reaction product was purified twice employing silica gel thin-layer chromatography using a thin chloroform:methanol (2:1) mixture as developing solvent to yield an 8-β-amino ethyltheophylline-carboxyfluorescein conjugate of the formula: ##STR10##

後処理

  1. customthe reaction product was purified twice employing silica gel thin-layer chromatography

出典と根拠

ORDレコード
ord-d7912e197081430b82dbad2178b728a4
出典データセット
uspto-grants-1991_11
特許番号
US05066426

反応ノート

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