Acetic Acid → 5-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-6-methyl-3H,6H-1,3,4-thiadiazin-2-one

HRID 973932

反応式

HRID 973932 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]([CH3:14])[S:12][C:11](=[O:15])[NH:10][N:9]=2)=[CH:4][CH:3]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.C(O)(=O)C>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:1]([C:2]2[CH:3]=[CH:4][C:5]([C:8]3[CH:13]([CH3:14])[S:12][C:11](=[O:15])[NH:10][N:9]=3)=[CH:6][CH:7]=2)[CH:17]=[CH:18]1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 79684H-pyran-4-oneHCID 224986135-(4-aminophenyl)-6-methyl-3H,6H-1,3,4-thiadiazine-2-one

生成物 1

HCID 197942225-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-6-methyl-3H,6H-1,3,4-thiadiazin-2-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A stirred mixture of 5-(4-aminophenyl)-6-methyl-3H,6H -1,3,4-thiadiazine-2-one (0.54 g). 4H-pyran-4-one (0.26 g), glacial acetic acid (0.15 g) and water (20 ml) was heated under reflux for 24 hours to give a solid. 0.54 g. Recrystallisation from aqueous ethanol gave the title compound, 0.28 g, which darkened at 265° C. and sublimed at 273-275° C.

後処理

  1. temperatureunder reflux for 24 hours
  2. customto give a solid
  3. customRecrystallisation from aqueous ethanol

出典と根拠

ORDレコード
ord-aff74887215d45388a8541de1e6858e6
出典データセット
uspto-grants-1991_11
特許番号
US05066653

関連ノート

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