Hydrazine hydrate (1:1) → 4,5-Dihydro-5-methyl-6-(4-(4-oxo-1(4H)-pyridinyl)phenyl)-3(2H)-pyridazinone

HRID 973941

反応式

HRID 973941 の反応式
O.[NH2:2][NH2:3].[O:4]=[C:5]1[CH:10]=[CH:9][N:8]([C:11]2[CH:24]=[CH:23][C:14]([C:15]([CH:17]([CH3:22])[CH2:18][C:19](O)=[O:20])=O)=[CH:13][CH:12]=2)[CH:7]=[CH:6]1>O>[CH3:22][CH:17]1[C:15]([C:14]2[CH:23]=[CH:24][C:11]([N:8]3[CH:9]=[CH:10][C:5](=[O:4])[CH:6]=[CH:7]3)=[CH:12][CH:13]=2)=[N:3][NH:2][C:19](=[O:20])[CH2:18]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 99477483-[4-(4-Oxo-1,4-dihydropyridin-1-yl)benzoyl]butanoic acid

生成物 1

HCID 1307024,5-Dihydro-5-methyl-6-(4-(4-oxo-1(4H)-pyridinyl)phenyl)-3(2H)-pyridazinone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Hydrazine hydrate (1.8 g) was added to a suspension of 3-[4-(4-oxo-1,4-dihydropyridin-1-yl)benzoyl]-butanoic acid (5 g) in water (60 ml). The resulting solution was stirred under reflux for 2 hours and cooled to afford the title compound as a pale yellow solid, 4.45 g. m.p. 255-258° C.

後処理

  1. temperatureunder reflux for 2 hours
  2. temperaturecooled

出典と根拠

ORDレコード
ord-9c2afb1006004f7ca2329051ff5f23b2
出典データセット
uspto-grants-1991_11
特許番号
US05066653

関連ノート

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