Iodoethane → 4-Acetylaminomethyl-1-ethylpyridinium iodide

HRID 973994ノート

反応式

HRID 973994 の反応式
[C:1]([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH2:12]([I:14])[CH3:13]>CC(C)=O>[I-:14].[C:1]([NH:4][CH2:5][C:6]1[CH:7]=[CH:8][N+:9]([CH2:12][CH3:13])=[CH:10][CH:11]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 6340IodoethaneHCID 289830N-(4-Pyridinylmethyl)acetamide

生成物 1

HCID 197755294-Acetylaminomethyl-1-ethylpyridinium iodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 4-acetylaminomethylpyridine (22.40 g) and ethyl iodide (17.9 ml) in acetone (300 ml) was heated under reflux for 24 hours and then the solvent was evaporated in vacuo. The residue was washed with a mixture of n-hexane, ethyl acetate and ethanol to give very hygroscopic 4-acetylaminomethyl-1-ethylpyridinium iodide (42.18 g), which was used without further purification.

後処理

  1. temperatureunder reflux for 24 hours
  2. customthe solvent was evaporated in vacuo
  3. washThe residue was washed with a mixture of n-hexane, ethyl acetate and ethanol

出典と根拠

ORDレコード
ord-069f3f8b64b54ec4a58710af73ad1bd1
出典データセット
uspto-grants-1991_11
特許番号
US05066680

反応ノート

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