N-(2-fluoro-4-nitrophenyl)acetamide → n-(4-Amino-2-fluorophenyl)acetamide

HRID 974142ノート

反応式

HRID 974142 の反応式
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[F:14])(=[O:3])[CH3:2]>[Pd].CO>[NH2:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[C:6]([F:14])[CH:7]=1

参加物

4

反応物 1

HCID 3412310N-(2-fluoro-4-nitrophenyl)acetamide

生成物 1

HCID 255648n-(4-Amino-2-fluorophenyl)acetamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

198 g (1 mol) of 1-acetylamino-2-fluoro-4-nitrobenzene are transferred into a stainless steel autoclave together with 510 ml of methanol, about 3 g of palladium-on-charcoal (5%) are added and catalytic reduction is carried out in the course of 4 hours at 50° C. under a hydrogen pressure of 15 bar. After the catalyst has been removed, 450 ml of methanol are distilled off from the reaction solution in vacuo, the product which has precipitated is filtered off with suction and the residue is washed with a little methanol and dried at 50°-60° C. in a vacuum cabinet.

後処理

  1. additionare added
  2. customis carried out in the course of 4 hours at 50° C. under a hydrogen
  3. customAfter the catalyst has been removed
  4. distillation450 ml of methanol are distilled off from the reaction solution in vacuo
  5. customthe product which has precipitated
  6. filtrationis filtered off with suction
  7. washthe residue is washed with a little methanol
  8. customdried at 50°-60° C. in a vacuum cabinet

出典と根拠

ORDレコード
ord-40574bfebfd848c6a0340bf2ca154c17
出典データセット
uspto-grants-1991_11
特許番号
US05067967

反応ノート

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