Potassium Carbonate → 2-Amino-6-(3-(3-chloro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974292

反応式

HRID 974292 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[CH:5]=[CH:6][CH2:7]Cl.[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[N:22]=1.C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl>[NH2:12][C:13]1[S:14][C:15]2[CH2:16][CH2:17][N:18]([CH2:7][CH:6]=[CH:5][C:4]3[CH:9]=[CH:10][CH:11]=[C:2]([Cl:1])[CH:3]=3)[CH2:19][CH2:20][C:21]=2[N:22]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 538328553-Chloro-cinnamyl chloride

生成物 1

HCID 536944422-Amino-6-(3-(3-chloro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine収率 20%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Prepared from 3-chloro-cinnamyl chloride and 1 equivalent of 2-amino-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine in chloroform in the presence of 1 equivalent of potassium carbonate. Yield: 20% of theory, Melting point: 132°-136° C.

出典と根拠

ORDレコード
ord-9f5e06e4392f4ef5a0ace45abf14d621
出典データセット
uspto-grants-1991_11
特許番号
US05068325

関連ノート

読み込み中…