Benzaldehyde → N-Benzylidene-2,4-difluorobenzylamine

HRID 974398

反応式

HRID 974398 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[CH:11](=O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.O>C1(C)C=CC=CC=1>[CH:11](=[N:5][CH2:4][C:3]1[CH:6]=[CH:7][C:8]([F:10])=[CH:9][C:2]=1[F:1])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 240BenzaldehydeHCID 962WaterHCID 27332442,4-Difluorobenzylamine

生成物 1

HCID 19986446N-Benzylidene-2,4-difluorobenzylamine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

50.2 g (0.35 mol) of 2,4-difluorobenzylamine and 37.1 g (0.35 mol) of benzaldehyde are dissolved in 140 ml of toluene and heated to reflux. The water produced is separated off using a water separator. The reaction is complete (GC check) after two hours. The solution is evaporated on a vacuum rotary evaporator. 78.9 g (97% of theory) of a slightly yellow liquid are obtained.

後処理

  1. temperatureheated to reflux
  2. customis separated off
  3. customafter two hours
  4. customThe solution is evaporated on a vacuum rotary evaporator
  5. custom78.9 g (97% of theory) of a slightly yellow liquid are obtained

出典と根拠

ORDレコード
ord-6267607942ce40488e1d03f6daa5f76d
出典データセット
uspto-grants-1991_11
特許番号
US05068371

関連ノート

読み込み中…