Triethylamine → HCID 15053433、化合物
反応式
C(O)(=O)C(O)=O.[F:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[O:11][CH:12]1[CH2:15][NH:14][CH2:13]1.[CH3:19][N:20]=[C:21]=[O:22].C(N(CC)CC)C>O1CCCC1.O>[F:7][C:8]1[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=1)[O:11][CH:12]1[CH2:15][N:14]([C:21]([NH:20][CH3:19])=[O:22])[CH2:13]1参加物
6
実験手順
A stirred mixture of 5.4 g (0.02 mole) of 3-(3-fluorophenoxy)-azetidine oxalate and 1.7 g (0.022 mole) of methyl isocyanate in 20 ml of tetrahydrofuran was treated with 5 ml of triethylamine then stirring was continued for 3 hr. The reaction was diluted with water and the fine crystalline precipitate obtained was collected by filtration and dried at 60° C. under vacuum to yield 3 g (66.9%) of product, m.p. 155°-156° C.
後処理
- customthe fine crystalline precipitate obtained
- filtrationwas collected by filtration
- customdried at 60° C. under vacuum
出典と根拠
- ORDレコード
- ord-626bcd61e5654808af8efaebe0934948
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05068231
反応ノート
読み込み中…