Ammonium Hydroxide → HCID 15053444、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10](Cl)=[O:11])[CH2:7]1.[OH-].[NH4+:17]>O1CCCC1.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]([NH2:17])=[O:11])[CH2:7]1参加物
5
実験手順
A solution of 5.8 g (0.02 mole) of 3-(3-bromophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred at ambient temperature while 4 ml (0.06 mole) of 57% ammonium hydroxide was slowly added. After stirring for 48 hr, the reaction mixture was diluted with 100 ml of water and the resulting solid collected by filtration (5 g). Recrystallization from isopropanol yielded 3.7 g (59%) of fine beige crystals, m.p. 188°-189° C.
後処理
- additionwas slowly added
- filtrationthe resulting solid collected by filtration (5 g)
- customRecrystallization from isopropanol
出典と根拠
- ORDレコード
- ord-ca5e6ed59cf0416195d6b9ac0fa0918e
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05068231
反応ノート
読み込み中…