Methylamine → HCID 15053445、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10](Cl)=[O:11])[CH2:7]1.[CH3:16][NH2:17]>O1CCCC1.O>[Br:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][CH:6]1[CH2:9][N:8]([C:10]([NH:17][CH3:16])=[O:11])[CH2:7]1参加物
5
実験手順
A stirred solution of 5.8 g (0.02 mole) of 3-(3-bromophenoxy)-1 -azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was treated with 4.7 g (0.06 mole) of 40 % aqueous monomethylamine. After stirring for 48 hr, the reaction mixture was diluted with 100 ml of water and the solid which formed was collected by filtration (6.0 g). Recrystallization from benzene yielded 2.0 g (35.1%) of tan crystals, m.p. 134°-135° C.
後処理
- customthe solid which formed
- filtrationwas collected by filtration (6.0 g)
- customRecrystallization from benzene
出典と根拠
- ORDレコード
- ord-af591cc670fd4630b3e47726e6791669
- 出典データセット
- uspto-grants-1991_11
- 特許番号
- US05068231
反応ノート
読み込み中…