Ammonium Hydroxide → HCID 15053448、化合物

HRID 974614ノート

反応式

HRID 974614 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11](Cl)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[OH-].[NH4+:17]>O1CCCC1.O>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([NH2:17])=[O:12])[CH2:8]2)=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 14923Ammonium HydroxideHCID 15042229HCID 15042229、化合物

生成物 1

HCID 15053448HCID 15053448、化合物収率 52.9%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 5 g (0.02 mole) of 3-(4-chlorophenoxy)-1-azetidinecarbonyl chloride in 20 ml of tetrahydrofuran was stirred while 4 ml (0.06 mole) of 57% ammonium hydroxide was added all at once. After stirring for 18 hr, the reaction mixture was diluted with 200 ml of water and the solid which separated was collected by filtration, 10.5 g. Recrystallization from isopropanol yielded 2.4 g (52.9%) of gray crystalline powder, m.p. 187°-188° C.

後処理

  1. additionwas added all at once
  2. customthe solid which separated
  3. filtrationwas collected by filtration, 10.5 g
  4. customRecrystallization from isopropanol

出典と根拠

ORDレコード
ord-c6eb296d65eb4e44aed771720a40f514
出典データセット
uspto-grants-1991_11
特許番号
US05068231

反応ノート

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