Hydrochloric Acid → HCID 19594629、化合物

HRID 974891ノート

反応式

HRID 974891 の反応式
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1.[ClH:17]>CO.[Pd]>[ClH:17].[ClH:17].[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

生成物 1

HCID 19594629HCID 19594629、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 4 g (18.2 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane in 100 ml of methanol and 3.5 ml of concentrated hydrochloric acid is hydrogenated on 2 g of palladium-on-active charcoal (10% of Pd) at 80° C. under 100 bar. The catalyst is filtered off and washed with water. The filtrates are concentrated and the product is crystallized by trituration with a little methanol. The crystals are filtered off with suction, washed with acetone and dried in air.

後処理

  1. filtrationThe catalyst is filtered off
  2. washwashed with water
  3. concentrationThe filtrates are concentrated
  4. customthe product is crystallized by trituration with a little methanol
  5. filtrationThe crystals are filtered off with suction
  6. washwashed with acetone
  7. customdried in air

出典と根拠

ORDレコード
ord-cb36726adaa84de2b616fdea56bf1283
出典データセット
uspto-grants-1997_03
特許番号
US05607942

反応ノート

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