Tetrafluoro-m-phenylenediamine dihydrochloride → 1-Methyloctahydropyrrolo[3,4-b]pyridine
反応式
C([N:8]1[CH2:16][CH:15]2[CH:10]([N:11]([CH3:17])[CH2:12][CH2:13][CH2:14]2)[CH2:9]1)C1C=CC=CC=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>CO.[Pd]>[CH3:17][N:11]1[CH2:12][CH2:13][CH2:14][CH:15]2[CH2:16][NH:8][CH2:9][CH:10]12参加物
5
実験手順
11.7 g (54 mmol) of 6-benzyl-1-methyl-octahydropyrrolo[3,4-b]pyridine as the dihydrochloride are hydrogenated in 100 ml of methanol over palladium-on-active charcoal in accordance with the working instructions of Example Id. Working up by distillation gives 2.6 g (34% of theory) of a colorless oil of boiling point 83°-85°/12 mbar).
後処理
- distillationWorking up by distillation
- customgives 2.6 g (34% of theory) of a colorless oil of boiling point 83°-85°/12 mbar)
出典と根拠
- ORDレコード
- ord-13102f10914547e6b823d90c7f3ee318
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05607942
反応ノート
読み込み中…