2,4-Difluoroaniline → 2,4-Difluorophenyl-3-methylurea

HRID 975759

反応式

HRID 975759 の反応式
[CH3:1][N:2]=[C:3]=[O:4].[F:5][C:6]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:7]=1[NH2:8]>C1(C)C=CC=CC=1>[F:5][C:6]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:7]=1[NH:8][C:3]([NH:2][CH3:1])=[O:4]

参加物

4

反応物 2

HCID 97092,4-DifluoroanilineHCID 12228Methyl Isocyanate

生成物 1

HCID 211615902,4-Difluorophenyl-3-methylurea

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Methyl isocyanate (9.6 g, 10 mL, 0.174 mol) is added to a solution of 2,4-difluoroaniline (15 g, 0.116 mol) in toluene. The reaction mixture is stirred for 1 hour and filtered to obtain a solid. The solid is washed with hexanes and air-dried to give the title product as an offwhite solid, mp 182°-183° C.

後処理

  1. filtrationfiltered
  2. customto obtain a solid
  3. washThe solid is washed with hexanes
  4. customair-dried

出典と根拠

ORDレコード
ord-990f6b9dbd1d4c988c22634393b77a9b
出典データセット
uspto-grants-1997_03
特許番号
US05610120

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