Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate → Methyl 3-(3,5-diisopropylbenzoyl)propionate

HRID 976352ノート

反応式

HRID 976352 の反応式
[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[C:17]=1OC1N(C2C=CC=CC=2)N=NN=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]>C1C=CC=CC=1.[Pd]>[CH:1]([C:4]1[CH:5]=[C:6]([CH:15]=[C:16]([CH:30]([CH3:32])[CH3:31])[CH:17]=1)[C:7]([CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[O:8])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 19967146Methyl 3-[3,5-Diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate

生成物 1

HCID 19967165Methyl 3-(3,5-diisopropylbenzoyl)propionate収率 71.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 241Benzene溶媒

実験手順

14.1 g of Methyl 3-[3,5-diisopropyl-4-(1-phenyltetrazol-5-yloxy)benzoyl]propionate was dissolved in 100 ml of benzene, followed by the addition of 10 g of 10% palladium/carbon. The obtained mixture was subjected to hydrogenation under a pressure of 3 kg/cm2, at room temperature for 14 hours. The reaction mixture thus obtained was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane) to give 6.4 g of the title compound as a colorless oil.

後処理

  1. customThe reaction mixture thus obtained
  2. filtrationwas filtered
  3. customto remove the catalyst
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customThe obtained residue was purified by silica gel chromatography (developer: 3% ethyl acetate/n-hexane)

出典と根拠

ORDレコード
ord-3a3b8643fb8147ee844d1f66562560c3
出典データセット
uspto-grants-1997_03
特許番号
US05612356

反応ノート

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